Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus

Suzana Hadjur, Luke M. Williams, Natalie K. Ryan, Bradley S. Cobb, Tom Sexton, Peter Fraser, Amanda G. Fisher and Matthias Merkenschlager ()
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Suzana Hadjur: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
Luke M. Williams: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
Natalie K. Ryan: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
Bradley S. Cobb: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
Tom Sexton: Laboratory of Chromatin and Gene Expression, The Babraham Institute
Peter Fraser: Laboratory of Chromatin and Gene Expression, The Babraham Institute
Amanda G. Fisher: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
Matthias Merkenschlager: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK

Nature, 2009, vol. 460, issue 7253, 410-413

Abstract: Cohesin branches out As well as its role in sister chromatid cohesion, the cohesin protein complex is thought be involved in the control of gene expression. Hadjur et al. show here that cohesin is involved topologically and mechanistically in long-range interactions at the cytokine locus IFNG.

Date: 2009
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DOI: 10.1038/nature08079

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