The AP-1 transcription factor Batf controls TH17 differentiation

Barbara U. Schraml, Kai Hildner, Wataru Ise, Wan-Ling Lee, Whitney A.-E. Smith, Ben Solomon, Gurmukh Sahota, Julia Sim, Ryuta Mukasa, Saso Cemerski, Robin D. Hatton, Gary D. Stormo, Casey T. Weaver, John H. Russell, Theresa L. Murphy and Kenneth M. Murphy ()
Additional contact information
Barbara U. Schraml: Department of Pathology and Immunology,
Kai Hildner: Department of Pathology and Immunology,
Wataru Ise: Department of Pathology and Immunology,
Wan-Ling Lee: Department of Pathology and Immunology,
Whitney A.-E. Smith: Department of Pathology and Immunology,
Ben Solomon: Department of Pathology and Immunology,
Gurmukh Sahota: Department of Genetics,
Julia Sim: Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA
Ryuta Mukasa: University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA
Saso Cemerski: Department of Pathology and Immunology,
Robin D. Hatton: University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA
Gary D. Stormo: Department of Genetics,
Casey T. Weaver: University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA
John H. Russell: Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA
Theresa L. Murphy: Department of Pathology and Immunology,
Kenneth M. Murphy: Department of Pathology and Immunology,

Nature, 2009, vol. 460, issue 7253, 405-409

Abstract: New role for AP-1/JUN AP-1 (activator protein-1) transcription factors, also known as JUN factors, are broadly acting factors regulating many inducible genetic responses. Schraml et al. report a surprising mechanism that expands the biological repertoire of the AP-1 family. They find that the AP-1 transcription factor Batf plays a critical role in the differentiation of IL17-producing T-helper cells.

Date: 2009
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DOI: 10.1038/nature08114

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