A conserved ubiquitination pathway determines longevity in response to diet restriction

Andrea C. Carrano, Zheng Liu, Andrew Dillin () and Tony Hunter
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Andrea C. Carrano: Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Zheng Liu: Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Andrew Dillin: Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Tony Hunter: Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA

Nature, 2009, vol. 460, issue 7253, 396-399

Abstract: Ubiquitination and longevity The fact that dietary restriction increases longevity in a range of different animal species suggests that there is a conserved mechanism at work. Carrano et al. now show that the E3 ubiquitin ligase WWP-1 is essential for such lifespan extension in the worm. The lifespan enhancing abilities of WWP-1 are specific to dietary restriction and require the transcription factor pha-4, and not the transcription factor daf-16 — best known for its involvement in lifespan extension via reduced insulin/IGF-1 signalling. This finding implicates the widely conserved ubiquitination pathway in the longevity response to dietary restriction.

Date: 2009
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DOI: 10.1038/nature08130

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