Regulation of the innate immune response by threonine-phosphatase of Eyes absent

Yasutaka Okabe, Teruyuki Sano and Shigekazu Nagata ()
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Yasutaka Okabe: Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Kyoto 606-8501, Japan
Teruyuki Sano: Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Kyoto 606-8501, Japan
Shigekazu Nagata: Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Kyoto 606-8501, Japan

Nature, 2009, vol. 460, issue 7254, 520-524

Abstract: EYA4 protein and innate immunity EYA4 (Eyes absent 4), was originally identified as a Drosophila transcription factor regulating eye development, and four EYA family proteins have since been identified in mammals. Here it is shown that the threonine phosphatase activity of EYA4 stimulates the innate immune response to apoptotic-cell-derived undigested DNA and enhances the response against cytosolic double-stranded RNA.

Date: 2009
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DOI: 10.1038/nature08138

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