Partial penetrance facilitates developmental evolution in bacteria

Avigdor Eldar, Vasant K. Chary, Panagiotis Xenopoulos, Michelle E. Fontes, Oliver C. Losón, Jonathan Dworkin, Patrick J. Piggot and Michael B. Elowitz ()
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Avigdor Eldar: California Institute of Technology, Pasadena, California 91125, USA
Vasant K. Chary: Temple University School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Panagiotis Xenopoulos: Temple University School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Michelle E. Fontes: California Institute of Technology, Pasadena, California 91125, USA
Oliver C. Losón: California Institute of Technology, Pasadena, California 91125, USA
Jonathan Dworkin: College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Patrick J. Piggot: Temple University School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Michael B. Elowitz: California Institute of Technology, Pasadena, California 91125, USA

Nature, 2009, vol. 460, issue 7254, 510-514

Abstract: The role of partial penetrance in development Geneticists have long known that individuals with exactly the same genetic make-up can differ from one another in their development and resulting phenotype, but the developmental and evolutionary significance of the phenomenon are not clear. The nature of this 'partial penetrance', whereby the effects of a mutation are observed only in some individuals, even in an isogenic population, has been studied using Bacillus subtilis sporulation as a model developmental system. The results suggest how mutations affecting DNA replication and cell division may act in synergy to facilitate the evolution of twin sporulation as a new trait, through progressive increases in its penetrance.

Date: 2009
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DOI: 10.1038/nature08150

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