Helical extension of the neuronal SNARE complex into the membrane

Alexander Stein, Gert Weber, Markus C. Wahl and Reinhard Jahn ()
Additional contact information
Alexander Stein: Department of Neurobiology,
Gert Weber: Research Group X-ray Crystallography, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany
Markus C. Wahl: Research Group X-ray Crystallography, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany
Reinhard Jahn: Department of Neurobiology,

Nature, 2009, vol. 460, issue 7254, 525-528

Abstract: Neuronal SNARE complex structure Neurotransmission critically relies on synaptic vesicles fusing with the membrane of nerve cells to release their neurotransmitter content into the synaptic cleft, a process requiring the assembly of several members of the SNARE protein family. Stein et al. have now solved the X-ray crystallographic structure of an extended neuronal SNARE complex, which suggest that these proteins operate like nanomachines whose zippering all the way into the membranes triggers their fusion. Other SNAREs are likely to function as such robust and simple membrane fusion catalysts during most secretory or endocytosis events in eukaryotes.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature08156 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:460:y:2009:i:7254:d:10.1038_nature08156

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08156

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().