Modulation of microRNA processing by p53

Hiroshi I. Suzuki, Kaoru Yamagata, Koichi Sugimoto, Takashi Iwamoto, Shigeaki Kato and Kohei Miyazono ()
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Hiroshi I. Suzuki: Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Kaoru Yamagata: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Koichi Sugimoto: Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
Takashi Iwamoto: College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan
Shigeaki Kato: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Kohei Miyazono: Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Nature, 2009, vol. 460, issue 7254, 529-533

Abstract: Link between p53 and miRNA The p53 tumour suppressor is a well known transcriptional activator with many growth suppressive targets. Disruption of p53 function is a fundamental event in the development of most cancers. MicroRNAs (miRNAs) have emerged as significant factors in tumour suppression, and in this work an unexpected link between p53 and miRNAs has been found. In an interaction that is independent of its role in regulating transcription, p53 enhances post-transcriptional maturation of several growth-suppressive miRNAs, including miR-16-1, miR-143 and miR-145, in response to DNA damage. This suggests that p53's ability to modulate miRNA biogenesis could contribute to its oncogenic potential.

Date: 2009
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DOI: 10.1038/nature08199

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