MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

Andrew S. Yoo, Brett T. Staahl, Lei Chen and Gerald R. Crabtree ()
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Andrew S. Yoo: Howard Hughes Medical Institute,
Brett T. Staahl: Howard Hughes Medical Institute,
Lei Chen: Howard Hughes Medical Institute,
Gerald R. Crabtree: Howard Hughes Medical Institute,

Nature, 2009, vol. 460, issue 7255, 642-646

Abstract: MicroRNA mediates key step in neurodevelopment A key step in the development of the vertebrate nervous system occurs when cells exit the multipotent neural stem cell state and enter a phase of post-mitotic neural development. This involves a switch in subunit composition of the SWI/SNF-like BAF chromatin remodelling complexes. Here, Yoo et al. show that the switch in BAF subunits is mediated by two microRNAs that are selectively expressed in post-mitotic neurons.

Date: 2009
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DOI: 10.1038/nature08139

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