Presenilins are essential for regulating neurotransmitter release

Chen Zhang, Bei Wu, Vassilios Beglopoulos, Mary Wines-Samuelson, Dawei Zhang, Ioannis Dragatsis, Thomas C. Südhof and Jie Shen ()
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Chen Zhang: Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
Bei Wu: Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
Vassilios Beglopoulos: Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
Mary Wines-Samuelson: Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
Dawei Zhang: Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
Ioannis Dragatsis: The University of Tennessee, Health Science Center, Memphis, Tennessee 38163, USA
Thomas C. Südhof: Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, California 94304, USA
Jie Shen: Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA

Nature, 2009, vol. 460, issue 7255, 632-636

Abstract: Presenilin action The presenilin genes have been genetically associated with familial cases of Alzheimer's disease but where they operate and what they do in neurons has been unclear. Zhang et al. demonstrate in mouse models that presinilins act in the presynaptic compartment to control activity-dependent neurotransmitter release, a process essential to neuronal computation, learning and memory. These findings suggest that presynaptic dysfunction might be an early cause of dementia in neurodegenerative disorders.

Date: 2009
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DOI: 10.1038/nature08177

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