Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements

Christoph Lepper (), Simon J. Conway and Chen-Ming Fan ()
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Christoph Lepper: Carnegie Institution, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
Simon J. Conway: Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Chen-Ming Fan: Carnegie Institution, 3520 San Martin Drive, Baltimore, Maryland 21218, USA

Nature, 2009, vol. 460, issue 7255, 627-631

Abstract: Muscle stem cells: satellite states The myogenic determinant Pax7 is thought to play a critical role in adult muscle stem cells — also known as satellite cells — but a formal demonstration has been lacking in vivo. Lepper et al. report the unexpected finding that when Pax7 is inactivated in adult mice, mutant satellite cells are not compromised in muscle regeneration, can self-renew and reoccupy the satellite niche, and support further regenerative processes. Pax7 is required only up to the juvenile period when progenitor cells transition into quiescence. The discovery of an age-dependent change in the genetic requirement for muscle stem cells cautions against inferring adult stem cell biology from embryonic studies and has direct implications for the use of stem cells from hosts of different ages in transplantation-based therapy.

Date: 2009
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DOI: 10.1038/nature08209

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