Switch in FGF signalling initiates glial differentiation in the Drosophila eye

Sigrídur Rut Franzdóttir, Daniel Engelen, Yeliz Yuva-Aydemir, Imke Schmidt, Annukka Aho and Christian Klämbt ()
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Sigrídur Rut Franzdóttir: Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany
Daniel Engelen: Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany
Yeliz Yuva-Aydemir: Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany
Imke Schmidt: Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany
Annukka Aho: Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany
Christian Klämbt: Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany

Nature, 2009, vol. 460, issue 7256, 758-761

Abstract: FGF signalling and glial regulation Glial cells play essential roles at all steps in the building and wiring of nervous systems. Franzdóttir et al. now identify proteins of the FGF-8 family secreted first by glial and then by neuronal cells during eye development in the fruit fly. These proteins respectively control the initial glial-cell proliferation and migration, then the switch to terminal glia differentiation and their wrapping and insulation of nerves. As the signalling pathways implicated have been conserved during evolution, genetics tools available in Drosophila should stimulate research on human neurological disorders involving glia.

Date: 2009
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DOI: 10.1038/nature08167

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