Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans

Johan Malmström, Martin Beck, Alexander Schmidt, Vinzenz Lange, Eric W. Deutsch and Ruedi Aebersold ()
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Johan Malmström: Institute of Molecular Systems Biology, ETH Zurich (Swiss Federal Institute of Technology), Wolfgang Pauli-Strasse 16, CH-8093 Zurich, Switzerland
Martin Beck: Institute of Molecular Systems Biology, ETH Zurich (Swiss Federal Institute of Technology), Wolfgang Pauli-Strasse 16, CH-8093 Zurich, Switzerland
Alexander Schmidt: Institute of Molecular Systems Biology, ETH Zurich (Swiss Federal Institute of Technology), Wolfgang Pauli-Strasse 16, CH-8093 Zurich, Switzerland
Vinzenz Lange: Institute of Molecular Systems Biology, ETH Zurich (Swiss Federal Institute of Technology), Wolfgang Pauli-Strasse 16, CH-8093 Zurich, Switzerland
Eric W. Deutsch: Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103-8904, USA
Ruedi Aebersold: Institute of Molecular Systems Biology, ETH Zurich (Swiss Federal Institute of Technology), Wolfgang Pauli-Strasse 16, CH-8093 Zurich, Switzerland

Nature, 2009, vol. 460, issue 7256, 762-765

Abstract: Proteins by numbers Absolute protein quantification via the measurement of protein copy numbers has the potential to provide important information about biological processes, but apart from the special case of brewers yeast, this has not proved possible using standard proteomics procedures. Now, with the leptospirosis pathogen Leptospira interrogans as the first target, a new mass spectrometry-based strategy that should be generally applicable to many other biological systems has been used to determine absolute protein abundance for a significant fraction of a proteome. The results show how L. interrogans adapts to changing environments by adjusting proteome homeostasis while the total protein copy numbers remain constant.

Date: 2009
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DOI: 10.1038/nature08184

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