Common variants conferring risk of schizophrenia

Hreinn Stefansson, Roel A. Ophoff, Stacy Steinberg, Ole A. Andreassen, Sven Cichon, Dan Rujescu, Thomas Werge, Olli P. H. Pietiläinen, Ole Mors, Preben B. Mortensen, Engilbert Sigurdsson, Omar Gustafsson, Mette Nyegaard, Annamari Tuulio-Henriksson, Andres Ingason, Thomas Hansen, Jaana Suvisaari, Jouko Lonnqvist, Tiina Paunio, Anders D. Børglum, Annette Hartmann, Anders Fink-Jensen, Merete Nordentoft, David Hougaard, Bent Norgaard-Pedersen, Yvonne Böttcher, Jes Olesen, René Breuer, Hans-Jürgen Möller, Ina Giegling, Henrik B. Rasmussen, Sally Timm, Manuel Mattheisen, István Bitter, János M. Réthelyi, Brynja B. Magnusdottir, Thordur Sigmundsson, Pall Olason, Gisli Masson, Jeffrey R. Gulcher, Magnus Haraldsson, Ragnheidur Fossdal, Thorgeir E. Thorgeirsson, Unnur Thorsteinsdottir, Mirella Ruggeri, Sarah Tosato, Barbara Franke, Eric Strengman, Lambertus A. Kiemeney, Ingrid Melle, Srdjan Djurovic, Lilia Abramova, Vasily Kaleda, Julio Sanjuan, Rosa de Frutos, Elvira Bramon, Evangelos Vassos, Gillian Fraser, Ulrich Ettinger, Marco Picchioni, Nicholas Walker, Timi Toulopoulou, Anna C. Need, Dongliang Ge, Joeng Lim Yoon, Kevin V. Shianna, Nelson B. Freimer, Rita M. Cantor, Robin Murray, Augustine Kong, Vera Golimbet, Angel Carracedo, Celso Arango, Javier Costas, Erik G. Jönsson, Lars Terenius, Ingrid Agartz, Hannes Petursson, Markus M. Nöthen, Marcella Rietschel, Paul M. Matthews, Pierandrea Muglia, Leena Peltonen, David St Clair, David B. Goldstein, Kari Stefansson () and David A. Collier
Additional contact information
Hreinn Stefansson: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Roel A. Ophoff: University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.
Stacy Steinberg: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Ole A. Andreassen: Ullevål University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166, N-0407 Oslo, Norway.
Sven Cichon: Life and Brain Center, University of Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany.
Dan Rujescu: Ludwig-Maximilians-University, Nußbaumstrasse 7, 80336 Munich, Germany.
Thomas Werge: Research Institute of Biological Psychiatry, Mental Health Centre Sct. Hans Copenhagen University Hospital, DK-4000 Roskilde, Denmark.
Olli P. H. Pietiläinen: Institute of Molecular Medicine, Biomedicum Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland.
Ole Mors: Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240 Risskov, Denmark.
Preben B. Mortensen: National Centre for Register-based Research, Aarhus University, Taasingegade 1, DK-8000 Aarhus, Denmark.
Engilbert Sigurdsson: National University Hospital, Hringbraut, 101 Reykjavik, Iceland.
Omar Gustafsson: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Mette Nyegaard: The Bartholin Building, Aarhus University, DK-8000 Arhus C, Denmark.
Annamari Tuulio-Henriksson: National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland.
Andres Ingason: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Thomas Hansen: Research Institute of Biological Psychiatry, Mental Health Centre Sct. Hans Copenhagen University Hospital, DK-4000 Roskilde, Denmark.
Jaana Suvisaari: National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland.
Jouko Lonnqvist: National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland.
Tiina Paunio: National Public Health Institute, Biomedicum, Haartmaninkatu 8, 00290 Helsinki, Finland.
Anders D. Børglum: Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240 Risskov, Denmark.
Annette Hartmann: Ludwig-Maximilians-University, Nußbaumstrasse 7, 80336 Munich, Germany.
Anders Fink-Jensen: Mental Health Centre Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen Ø, Denmark.
Merete Nordentoft: Psychiatric Centre Bisbebjerg, Building 13A, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark.
David Hougaard: Section of Neonatal Screening and Hormones, The State Serum Institute, Artillerivej 5, 2300 Copenhagen S, Denmark.
Bent Norgaard-Pedersen: Section of Neonatal Screening and Hormones, The State Serum Institute, Artillerivej 5, 2300 Copenhagen S, Denmark.
Yvonne Böttcher: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Jes Olesen: 57 Nordre Ringvej, Glostrup Hospital, Glostrup, DK-2600 Copenhagen, Denmark.
René Breuer: Central Institute of Mental Health, University of Heidelberg, J5, D-68159 Mannheim, Germany.
Hans-Jürgen Möller: Ludwig-Maximilians-University, Nußbaumstrasse 7, 80336 Munich, Germany.
Ina Giegling: Ludwig-Maximilians-University, Nußbaumstrasse 7, 80336 Munich, Germany.
Henrik B. Rasmussen: Research Institute of Biological Psychiatry, Mental Health Centre Sct. Hans Copenhagen University Hospital, DK-4000 Roskilde, Denmark.
Sally Timm: Mental Health Centre Frederiksberg, Copenhagen University Hospital, DK-2000 Frederiksberg, Denmark.
Manuel Mattheisen: Life and Brain Center, University of Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany.
István Bitter: Semmelweis University, Budapest 1083, Hungary.
János M. Réthelyi: Semmelweis University, Budapest 1083, Hungary.
Brynja B. Magnusdottir: National University Hospital, Hringbraut, 101 Reykjavik, Iceland.
Thordur Sigmundsson: National University Hospital, Hringbraut, 101 Reykjavik, Iceland.
Pall Olason: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Gisli Masson: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Jeffrey R. Gulcher: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Magnus Haraldsson: National University Hospital, Hringbraut, 101 Reykjavik, Iceland.
Ragnheidur Fossdal: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Thorgeir E. Thorgeirsson: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Unnur Thorsteinsdottir: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Mirella Ruggeri: Section of Psychiatry and Clinical Psychology, University of Verona, Verona, 37134 Verona, Italy.
Sarah Tosato: Section of Psychiatry and Clinical Psychology, University of Verona, Verona, 37134 Verona, Italy.
Barbara Franke: Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Eric Strengman: University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.
Lambertus A. Kiemeney: Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Ingrid Melle: Ullevål University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166, N-0407 Oslo, Norway.
Srdjan Djurovic: Ulleval University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166, N-0407 Oslo, Norway.
Lilia Abramova: Mental Health Research Center, Russian Academy of Medical Sciences, Zagorodnoe sh. 2/2, 117152 Moscow, Russia.
Vasily Kaleda: Mental Health Research Center, Russian Academy of Medical Sciences, Zagorodnoe sh. 2/2, 117152 Moscow, Russia.
Julio Sanjuan: Unidad de Psiquiatría, Facultad de Medicina, Universidad de Valencia, CIBERSAM, 46010 Valencia, Spain.
Rosa de Frutos: Universidad de Valencia, CIBERSAM, Spain.
Elvira Bramon: Institute of Psychiatry, King’s College, London SE5 8AF, UK.
Evangelos Vassos: Institute of Psychiatry, King’s College, London SE5 8AF, UK.
Gillian Fraser: University of Aberdeen, Royal Cornhill Hospital, Aberdeen AB25 2ZD, UK.
Ulrich Ettinger: Institute of Psychiatry, King’s College, London SE5 8AF, UK.
Marco Picchioni: Institute of Psychiatry, King’s College, London SE5 8AF, UK.
Nicholas Walker: Ravenscraig hospital, Inverkip Road, Greenock PA16 9HA, UK.
Timi Toulopoulou: Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College, London SE5 8AF, UK.
Anna C. Need: Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, 4011 GSRB II 103 Research Drive, Duke University, DUMC Box 3471, Durham, North Carolina 27708, USA.
Dongliang Ge: Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, 4011 GSRB II 103 Research Drive, Duke University, DUMC Box 3471, Durham, North Carolina 27708, USA.
Joeng Lim Yoon: UCLA, 695 Charles Young Drive South, Los Angeles, California 90095, USA.
Kevin V. Shianna: Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, 4011 GSRB II 103 Research Drive, Duke University, DUMC Box 3471, Durham, North Carolina 27708, USA.
Nelson B. Freimer: UCLA Center for Neurobehavioral Genetics, Charles E. Young Drive South, Los Angeles, California 90024, USA.
Rita M. Cantor: UCLA Center for Neurobehavioral Genetics, Charles E. Young Drive South, Los Angeles, California 90024, USA.
Robin Murray: Institute of Psychiatry, King’s College, London SE5 8AF, UK.
Augustine Kong: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
Vera Golimbet: Mental Health Research Center, Russian Academy of Medical Sciences, Zagorodnoe sh. 2/2, 117152 Moscow, Russia.
Angel Carracedo: Fundación Pública Galega de Medicina Xenómica-Complexo Universitario Hospitalario de Santiago, and CIBER de Enfermedades Raras (CIBERER), IML- Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Celso Arango: Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain.
Javier Costas: Fundación Pública Galega de Medicina Xenómica, and CIBER de Enfermedades Raras (CIBERER), 46010 Valencia, Spain.
Erik G. Jönsson: HUBIN project, Karolinska Institutet and Hospital, R5:00, SE-171 76 Stockholm, Sweden.
Lars Terenius: HUBIN project, Karolinska Institutet and Hospital, R5:00, SE-171 76 Stockholm, Sweden.
Ingrid Agartz: HUBIN project, Karolinska Institutet and Hospital, R5:00, SE-171 76 Stockholm, Sweden.
Hannes Petursson: National University Hospital, Hringbraut, 101 Reykjavik, Iceland.
Markus M. Nöthen: Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D-53111 Bonn, Germany.
Marcella Rietschel: Central Institute of Mental Health, University of Heidelberg, J5, D-68159 Mannheim, Germany.
Paul M. Matthews: Clinical Imaging Centre, Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Hammersmith Hospital, London W12 ONN, UK.
Pierandrea Muglia: Medical Genetics, GlaxoSmithKline R&D, Via A. Fleming 4, 37135 Verona, Italy.
Leena Peltonen: Institute of Molecular Medicine, Biomedicum Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland.
David St Clair: University of Aberdeen, Royal Cornhill Hospital, Aberdeen AB25 2ZD, UK.
David B. Goldstein: Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, 4011 GSRB II 103 Research Drive, Duke University, DUMC Box 3471, Durham, North Carolina 27708, USA.
Kari Stefansson: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
David A. Collier: Institute of Psychiatry, King’s College, London SE5 8AF, UK.

Nature, 2009, vol. 460, issue 7256, 744-747

Abstract: Schizophrenia: common variants identified Based on its symptoms, schizophrenia has been considered a discrete disease, and yet genome-wide association studies for copy number variations (CNVs) associated with the disease have revealed that some CNVs confer high relative risk of schizophrenia but also of other psychiatric disorders. But CNVs can affect several genes. Now, a genome-wide association of single nucleotide polymorphisms (SNPs) using data from several large genome-wide scans reveals significant associations to individual loci that implicate immunity, brain development, memory and cognition in predisposition to schizophrenia.

Date: 2009
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DOI: 10.1038/nature08186

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