Common variants on chromosome 6p22.1 are associated with schizophrenia

Jianxin Shi, Douglas F. Levinson, Jubao Duan, Alan R. Sanders, Yonglan Zheng, Itsik Pe’er, Frank Dudbridge, Peter A. Holmans, Alice S. Whittemore, Bryan J. Mowry, Ann Olincy, Farooq Amin, C. Robert Cloninger, Jeremy M. Silverman, Nancy G. Buccola, William F. Byerley, Donald W. Black, Raymond R. Crowe, Jorge R. Oksenberg, Daniel B. Mirel, Kenneth S. Kendler, Robert Freedman and Pablo V. Gejman ()
Additional contact information
Jianxin Shi: Stanford University, Stanford, California 94304, USA
Douglas F. Levinson: Stanford University, Stanford, California 94304, USA
Jubao Duan: Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA
Alan R. Sanders: Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA
Yonglan Zheng: Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA
Itsik Pe’er: Columbia University, New York, New York 10027, USA
Frank Dudbridge: Medical Research Council-Biostatistics Unit, Institute of Public Health
Peter A. Holmans: MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Heath Park, Cardiff CF23 6BQ, UK
Alice S. Whittemore: Stanford University, Stanford, California 94304, USA
Bryan J. Mowry: Queensland Centre for Mental Health Research, and Queensland Institute for Medical Research, Brisbane, Queensland 4072, Australia
Ann Olincy: University of Colorado Denver, Aurora, Colorado 80045, USA
Farooq Amin: Atlanta Veterans Affairs Medical Center, and Emory University, Atlanta, Georgia 30322, USA
C. Robert Cloninger: Washington University, St Louis, Missouri 63110, USA
Jeremy M. Silverman: Mount Sinai School of Medicine, New York, New York 10029, USA
Nancy G. Buccola: School of Nursing, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
William F. Byerley: University of California at San Francisco, San Francisco, California 94143, USA
Donald W. Black: Mental Health Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Raymond R. Crowe: Mental Health Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Jorge R. Oksenberg: School of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
Daniel B. Mirel: Center for Genotyping and Analysis, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA
Kenneth S. Kendler: and Human Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Robert Freedman: University of Colorado Denver, Aurora, Colorado 80045, USA
Pablo V. Gejman: Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA

Nature, 2009, vol. 460, issue 7256, 753-757

Abstract: Schizophrenia risk: link to chromosome 6p22.1 A genome-wide association study using the Molecular Genetics of Schizophrenia case-control data set, followed by a meta-analysis that included over 8,000 cases and 19,000 controls, revealed that while common genetic variation that underlies risk to schizophrenia can be identified, there probably are few or no single common loci with large effects. The common variants identified here lie on chromosome 6p22.1 in a region that includes a histone gene cluster and several genes implicated in immunity.

Date: 2009
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DOI: 10.1038/nature08192

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