Programming cells by multiplex genome engineering and accelerated evolution

Harris H. Wang (), Farren J. Isaacs (), Peter A. Carr, Zachary Z. Sun, George Xu, Craig R. Forest and George M. Church
Additional contact information
Harris H. Wang: Harvard Medical School, Boston, Massachusetts 02115, USA
Farren J. Isaacs: Harvard Medical School, Boston, Massachusetts 02115, USA
Peter A. Carr: The Center for Bits and Atoms,
Zachary Z. Sun: Harvard College, Cambridge, Massachusetts 02138, USA
George Xu: Harvard College, Cambridge, Massachusetts 02138, USA
Craig R. Forest: George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
George M. Church: Harvard Medical School, Boston, Massachusetts 02115, USA

Nature, 2009, vol. 460, issue 7257, 894-898

Abstract: Generating genomic diversity Genomic diversity is difficult to generate in the laboratory in an efficient way. A new technique called MAGE (multiplex automated genome engineering), described here, simultaneously targets many locations on the chromosome for modification in a single cell or across a population of cells, thereby producing combinatorial genomic diversity. This is an automated and efficient approach that expedites the design and evolution of organisms with new and improved properties.

Date: 2009
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DOI: 10.1038/nature08187

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