A role for Lin28 in primordial germ-cell development and germ-cell malignancy

Jason A. West, Srinivas R. Viswanathan, Akiko Yabuuchi, Kerianne Cunniff, Ayumu Takeuchi, In-Hyun Park, Julia E. Sero, Hao Zhu, Antonio Perez-Atayde, A. Lindsay Frazier, M. Azim Surani and George Q. Daley ()
Additional contact information
Jason A. West: Children’s Hospital Boston and the Dana-Farber Cancer Institute
Srinivas R. Viswanathan: Children’s Hospital Boston and the Dana-Farber Cancer Institute
Akiko Yabuuchi: Children’s Hospital Boston and the Dana-Farber Cancer Institute
Kerianne Cunniff: Children’s Hospital Boston and the Dana-Farber Cancer Institute
Ayumu Takeuchi: Children’s Hospital Boston and the Dana-Farber Cancer Institute
In-Hyun Park: Children’s Hospital Boston and the Dana-Farber Cancer Institute
Julia E. Sero: Children’s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Hao Zhu: Children’s Hospital Boston and the Dana-Farber Cancer Institute
Antonio Perez-Atayde: Children’s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
A. Lindsay Frazier: Children’s Hospital Boston and the Dana-Farber Cancer Institute
M. Azim Surani: Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
George Q. Daley: Children’s Hospital Boston and the Dana-Farber Cancer Institute

Nature, 2009, vol. 460, issue 7257, 909-913

Abstract: Reproductive cell formation An RNA interference screen of 30 gene candidates has identified Lin28, a negative regulator of let-7 microRNA processing, as a potentially key regulator of primordial germ cell development, the process in the developing embryo that selects the cells destined to produce sperm and eggs. In addition, Lin28 levels are elevated in primary human germ cell tumours, suggesting that it may also be implicated in germ cell malignancy.

Date: 2009
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature08210 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:460:y:2009:i:7257:d:10.1038_nature08210

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08210

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().