Neurotransmission selectively regulates synapse formation in parallel circuits in vivo

Daniel Kerschensteiner (), Josh L. Morgan, Edward D. Parker, Renate M. Lewis and Rachel O. L. Wong ()
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Daniel Kerschensteiner: Washington University School of Medicine, St Louis, Missouri 63110, USA
Josh L. Morgan: Washington University School of Medicine, St Louis, Missouri 63110, USA
Edward D. Parker: University of Washington, Seattle, Washington 98195, USA
Renate M. Lewis: Washington University School of Medicine, St Louis, Missouri 63110, USA
Rachel O. L. Wong: Washington University School of Medicine, St Louis, Missouri 63110, USA

Nature, 2009, vol. 460, issue 7258, 1016-1020

Abstract: Activity-dependent synapse formation Activity is presumed to help shape the connectivity within neural circuits, with differences often leading to the elimination of less active connections. Here, to challenge this notion, a subpopulation of bipolar cells was inactivated during development, yet retinal ganglion cells still received input from them, albeit through fewer synapses. This occurred through a reduced rate of synapse formation rather than an increase in synapse elimination. Synaptogenesis and connectivity within a parallel processing stream of bipolar cell input converging onto the same retinal ganglion cell were unaffected. These observations reveal an unexpected and independent role for activity in regulating the rate of synapse formation rather than elimination for specific set of inputs during circuit formation in vivo.

Date: 2009
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DOI: 10.1038/nature08236

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