In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

Yasushi Itoh, Kyoko Shinya, Maki Kiso, Tokiko Watanabe, Yoshihiro Sakoda, Masato Hatta, Yukiko Muramoto, Daisuke Tamura, Yuko Sakai-Tagawa, Takeshi Noda, Saori Sakabe, Masaki Imai, Yasuko Hatta, Shinji Watanabe, Chengjun Li, Shinya Yamada, Ken Fujii, Shin Murakami, Hirotaka Imai, Satoshi Kakugawa, Mutsumi Ito, Ryo Takano, Kiyoko Iwatsuki-Horimoto, Masayuki Shimojima, Taisuke Horimoto, Hideo Goto, Kei Takahashi, Akiko Makino, Hirohito Ishigaki, Misako Nakayama, Masatoshi Okamatsu, Kazuo Takahashi, David Warshauer, Peter A. Shult, Reiko Saito, Hiroshi Suzuki, Yousuke Furuta, Makoto Yamashita, Keiko Mitamura, Kunio Nakano, Morio Nakamura, Rebecca Brockman-Schneider, Hiroshi Mitamura, Masahiko Yamazaki, Norio Sugaya, M. Suresh, Makoto Ozawa, Gabriele Neumann, James Gern, Hiroshi Kida, Kazumasa Ogasawara and Yoshihiro Kawaoka ()
Additional contact information
Yasushi Itoh: Shiga University of Medical Science, Ohtsu, Shiga 520-2192, Japan
Kyoko Shinya: Kobe University
Maki Kiso: Institute of Medical Science, University of Tokyo
Tokiko Watanabe: University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
Yoshihiro Sakoda: Graduate School of Veterinary Medicine, Hokkaido University
Masato Hatta: University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
Yukiko Muramoto: ERATO Infection-Induced Host Responses Project
Daisuke Tamura: Institute of Medical Science, University of Tokyo
Yuko Sakai-Tagawa: Institute of Medical Science, University of Tokyo
Takeshi Noda: International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo
Saori Sakabe: Institute of Medical Science, University of Tokyo
Masaki Imai: University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
Yasuko Hatta: University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
Shinji Watanabe: University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
Chengjun Li: University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
Shinya Yamada: Institute of Medical Science, University of Tokyo
Ken Fujii: Institute of Medical Science, University of Tokyo
Shin Murakami: Institute of Medical Science, University of Tokyo
Hirotaka Imai: Institute of Medical Science, University of Tokyo
Satoshi Kakugawa: Institute of Medical Science, University of Tokyo
Mutsumi Ito: Institute of Medical Science, University of Tokyo
Ryo Takano: Institute of Medical Science, University of Tokyo
Kiyoko Iwatsuki-Horimoto: Institute of Medical Science, University of Tokyo
Masayuki Shimojima: Institute of Medical Science, University of Tokyo
Taisuke Horimoto: Institute of Medical Science, University of Tokyo
Hideo Goto: Institute of Medical Science, University of Tokyo
Kei Takahashi: Institute of Medical Science, University of Tokyo
Akiko Makino: Kobe University
Hirohito Ishigaki: Shiga University of Medical Science, Ohtsu, Shiga 520-2192, Japan
Misako Nakayama: Shiga University of Medical Science, Ohtsu, Shiga 520-2192, Japan
Masatoshi Okamatsu: Graduate School of Veterinary Medicine, Hokkaido University
Kazuo Takahashi: Osaka Prefectural Institute of Public Health
David Warshauer: Wisconsin State Laboratory of Hygiene, Madison, Wisconsin 53706, USA
Peter A. Shult: Wisconsin State Laboratory of Hygiene, Madison, Wisconsin 53706, USA
Reiko Saito: Niigata University, Graduate School of Medical and Dental Sciences
Hiroshi Suzuki: Niigata University, Graduate School of Medical and Dental Sciences
Yousuke Furuta: Toyama Chemical Co., Ltd.
Makoto Yamashita: Daiichi Sankyo Co Ltd, Shinagawa, Tokyo 140–8710, Japan
Keiko Mitamura: Eiju General Hospital
Kunio Nakano: Eiju General Hospital
Morio Nakamura: Eiju General Hospital
Rebecca Brockman-Schneider: School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA
Hiroshi Mitamura: Mitamura Clinic
Masahiko Yamazaki: Zama Children’s Clinic
Norio Sugaya: Keiyu Hospital
M. Suresh: University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
Makoto Ozawa: University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
Gabriele Neumann: University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
James Gern: School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA
Hiroshi Kida: Graduate School of Veterinary Medicine, Hokkaido University
Kazumasa Ogasawara: Shiga University of Medical Science, Ohtsu, Shiga 520-2192, Japan
Yoshihiro Kawaoka: Kobe University

Nature, 2009, vol. 460, issue 7258, 1021-1025

Abstract: Pandemic virus characterized Analysis of a series of clinical isolates of the swine-origin H1N1 influenza virus reveals that in mammalian models (mice, ferrets and macaques) the current pandemic virus is associated with more severe disease than a seasonal H1N1 strain. The viruses can also infect pigs but do not cause clinical signs. All antivirus drugs tested, including Tamiflu, were effective in cell culture against the new virus, lending support to the use of these compounds as a first line of defence against the pandemic.

Date: 2009
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DOI: 10.1038/nature08260

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