EBI2 mediates B cell segregation between the outer and centre follicle

João P. Pereira, Lisa M. Kelly, Ying Xu and Jason G. Cyster ()
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João P. Pereira: University of California San Francisco, California 94143, USA
Lisa M. Kelly: University of California San Francisco, California 94143, USA
Ying Xu: University of California San Francisco, California 94143, USA
Jason G. Cyster: University of California San Francisco, California 94143, USA

Nature, 2009, vol. 460, issue 7259, 1122-1126

Abstract: B-cell segregation: a role for orphan receptor EB12 The correct positioning of B cells within lymphoid follicles is critical for mounting antibody responses, and positioning of activated B cells in interfollicular regions and in the outer follicle is also thought to be important for supporting normal interactions between T cells and B cells and normal B-cell proliferation. The molecular cues controlling these positioning events have been unknown. Pereira et al. now establish that EBI2, an orphan G-protein-coupled receptor upregulated by Epstein–Barr virus infection, promotes B-cell positioning in the outer follicle. By down-regulating EBI2, germinal centre B cells are able to move to the follicle centre. Mice lacking or mis-expressing this receptor are shown to mount defective antibody responses.

Date: 2009
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DOI: 10.1038/nature08226

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