The Ink4/Arf locus is a barrier for iPS cell reprogramming

Han Li, Manuel Collado, Aranzazu Villasante, Katerina Strati, Sagrario Ortega, Marta Cañamero, Maria A. Blasco and Manuel Serrano ()
Additional contact information
Han Li: Tumor Suppression Group,
Manuel Collado: Tumor Suppression Group,
Aranzazu Villasante: Tumor Suppression Group,
Katerina Strati: Telomeres and Telomerase Group,
Sagrario Ortega: Transgenic Mice Unit,
Marta Cañamero: Comparative Pathology Unit, Spanish National Cancer Research Centre (CNIO), 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain
Maria A. Blasco: Telomeres and Telomerase Group,
Manuel Serrano: Tumor Suppression Group,

Nature, 2009, vol. 460, issue 7259, 1136-1139

Abstract: On iPS cells and p53: the Ink4/Arf barrier The Ink4/Arf tumour suppressor locus encodes three potent tumour suppressors, namely p16Ink4a, p15Ink4b and p19Arf. Here Li et al. show that the locus is rate limiting for reprogramming, and its transient inhibition significantly improves the generation of iPS cells. The also show ageing upregulates the Ink4/Arf locus and, accordingly, reprogramming is less efficient in cells from old organisms.

Date: 2009
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DOI: 10.1038/nature08290

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