iPS cells produce viable mice through tetraploid complementation

Xiao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao, Chang-long Guo, Qing-wen Ma, Liu Wang, Fanyi Zeng () and Qi Zhou ()
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Xiao-yang Zhao: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Wei Li: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Zhuo Lv: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Lei Liu: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Man Tong: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Tang Hai: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Jie Hao: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Chang-long Guo: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Qing-wen Ma: Shanghai Institute of Medical Genetics, Shanghai Children’s Hospital, Shanghai Jiao Tong University
Liu Wang: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Fanyi Zeng: Shanghai Institute of Medical Genetics, Shanghai Children’s Hospital, Shanghai Jiao Tong University
Qi Zhou: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences

Nature, 2009, vol. 461, issue 7260, 86-90

Abstract: Mice from iPS cells Since iPS (induced pluripotent stem) cells arrived on the scene in 2006, their properties have been measured against the yardstick of the true embryonic stem cells that they mimic. A clutch of recent papers, two of them published in this issue, reports the production of viable adult mice from iPS cells, a notable technical feat that shows that these cells are very close indeed to embryonic cells in their potential to produce cells for all tissues and all organs. Zhao et al. used a technique called tetraploid complementation, in which chimaeric mice are generated from injected pluripotent cells, and the embryonic tissue is derived solely from the injected cells. Boland et al. produced fertile adult mice derived entirely from iPS cells generated by inducible genetic reprogramming of mouse embryonic fibroblasts. The availability of these mice will provide a new resource for the study of iPS cell-derived tissues for both research and cell replacement therapy applications.

Date: 2009
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DOI: 10.1038/nature08267

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