Structure of a tetrameric MscL in an expanded intermediate state

Zhenfeng Liu, Chris S. Gandhi and Douglas C. Rees ()
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Zhenfeng Liu: California Institute of Technology, Pasadena, California 91125, USA
Chris S. Gandhi: California Institute of Technology, Pasadena, California 91125, USA
Douglas C. Rees: California Institute of Technology, Pasadena, California 91125, USA

Nature, 2009, vol. 461, issue 7260, 120-124

Abstract: MscL channel structure Mechanosensitive channels protect bacteria from osmotic shock by allowing ions to flow across the membrane in response to changes in membrane tension. MscL is one such channel with large conductance, which exhibits several intermediate states between its closed and open forms. The 3.8-Å crystal structure of the Staphylococcus aureus MscL has now been determined in a nonconductive, partially expanded and tetrameric form.

Date: 2009
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DOI: 10.1038/nature08277

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