Scaling of BMP gradients in Xenopus embryos

Paul Francois, Alin Vonica, Ali H. Brivanlou and Eric D. Siggia
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Paul Francois: *Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA. siggiae@rockefeller.edu
Alin Vonica: †Laboratory of Molecular Vertebrate Embryology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Ali H. Brivanlou: †Laboratory of Molecular Vertebrate Embryology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Eric D. Siggia: *Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA. siggiae@rockefeller.edu

Nature, 2009, vol. 461, issue 7260, E1-E1

Abstract: Abstract Arising from: D. Ben-Zvi et al. Nature 453, 1205–1211 (2008)10.1038/nature07059 ; Francois et al. reply Metazoan organisms can ‘scale’, that is, maintain similar proportions regardless of size. Ben-Zvi et al.1 use experiments in Xenopus to support a quantitative model that explains morphological scaling as the result of scaling of a gradient of bone morphogenetic protein (BMP) signals. We believe that the evidence for scaling in Xenopus is misinterpreted, and that their model for embryonic patterning disagrees with prior data. The experiments they present supporting their model admit alternative interpretations.

Date: 2009
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DOI: 10.1038/nature08305

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