Adult mice generated from induced pluripotent stem cells

Michael J. Boland, Jennifer L. Hazen, Kristopher L. Nazor (), Alberto R. Rodriguez, Wesley Gifford, Greg Martin, Sergey Kupriyanov and Kristin K. Baldwin ()
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Michael J. Boland: Department of Cell Biology,
Jennifer L. Hazen: Department of Cell Biology,
Kristopher L. Nazor: Department of Cell Biology,
Alberto R. Rodriguez: Mouse Genetics Core Facility, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Wesley Gifford: Medical Scientist Training Program, University of California, San Diego, La Jolla, California 92037, USA
Greg Martin: Mouse Genetics Core Facility, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Sergey Kupriyanov: Mouse Genetics Core Facility, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Kristin K. Baldwin: Department of Cell Biology,

Nature, 2009, vol. 461, issue 7260, 91-94

Abstract: Mice from iPS cells Since iPS (induced pluripotent stem) cells arrived on the scene in 2006, their properties have been measured against the yardstick of the true embryonic stem cells that they mimic. A clutch of recent papers, two of them published in this issue, reports the production of viable adult mice from iPS cells, a notable technical feat that shows that these cells are very close indeed to embryonic cells in their potential to produce cells for all tissues and all organs. Zhao et al. used a technique called tetraploid complementation, in which chimaeric mice are generated from injected pluripotent cells, and the embryonic tissue is derived solely from the injected cells. Boland et al. produced fertile adult mice derived entirely from iPS cells generated by inducible genetic reprogramming of mouse embryonic fibroblasts. The availability of these mice will provide a new resource for the study of iPS cell-derived tissues for both research and cell replacement therapy applications.

Date: 2009
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DOI: 10.1038/nature08310

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