Reptilian heart development and the molecular basis of cardiac chamber evolution

Kazuko Koshiba-Takeuchi, Alessandro D. Mori, Bogac L. Kaynak, Judith Cebra-Thomas, Tatyana Sukonnik, Romain O. Georges, Stephany Latham, Laural Beck, R. Mark Henkelman, Brian L. Black, Eric N. Olson, Juli Wade, Jun K. Takeuchi, Mona Nemer, Scott F. Gilbert and Benoit G. Bruneau ()
Additional contact information
Kazuko Koshiba-Takeuchi: Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Alessandro D. Mori: Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Bogac L. Kaynak: Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Judith Cebra-Thomas: Millersville University, Millersville, Pennsylvania 17551, USA
Tatyana Sukonnik: Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Romain O. Georges: Institut de Recherches Cliniques de Montréal, Programme de Biologie Moléculaire, Université de Montréal, Montréal, Québec H3C 3J7, Canada
Stephany Latham: Michigan State University, East Lansing, Michigan 48824, USA
Laural Beck: Michigan State University, East Lansing, Michigan 48824, USA
R. Mark Henkelman: The Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Brian L. Black: Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
Eric N. Olson: University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Juli Wade: Michigan State University, East Lansing, Michigan 48824, USA
Jun K. Takeuchi: Global-Edge Institute, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8503, Japan
Mona Nemer: Institut de Recherches Cliniques de Montréal, Programme de Biologie Moléculaire, Université de Montréal, Montréal, Québec H3C 3J7, Canada
Scott F. Gilbert: Swarthmore College, Swarthmore, Pennsylvania 19081, USA
Benoit G. Bruneau: Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA

Nature, 2009, vol. 461, issue 7260, 95-98

Abstract: Heart to heart Birds, mammals and crocodiles have hearts with two separate ventricles, servicing separate pulmonary and systemic circulations. Amphibians have just one ventricle, but in most reptiles, the situation is unclear. A new embryological study of a lizard (the green anole) and a turtle (the slider turtle) shows that the division of an ancestral single ventricle into two chambers is related to the expression of the T-box transcription factor Tbx5. In embryonic birds and mammals, Tbx5 expression is restricted to precursors of the left ventricle. In turtles and lizards, Tbx5 is initially expressed throughout the ventricle, but in turtles (though not lizards) it is later restricted to the left side of the chamber. This identifies altered Tbx5 expression as a possible evolutionary force driving embryonic heart patterning to provide the key adaptation to high-energy terrestrial life, the fully septated heart. In line with this idea, mice in which Tbx5 function is lost or expanded develop a single chamber lacking distinct identity.

Date: 2009
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DOI: 10.1038/nature08324

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