Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

Michael R. Elliott, Faraaz B. Chekeni, Paul C. Trampont, Eduardo R. Lazarowski, Alexandra Kadl, Scott F. Walk, Daeho Park, Robin I. Woodson, Marina Ostankovich, Poonam Sharma, Jeffrey J. Lysiak, T. Kendall Harden, Norbert Leitinger and Kodi S. Ravichandran ()
Additional contact information
Michael R. Elliott: Beirne B. Carter Center for Immunology Research,
Faraaz B. Chekeni: Beirne B. Carter Center for Immunology Research,
Paul C. Trampont: Beirne B. Carter Center for Immunology Research,
Eduardo R. Lazarowski: Department of Medicine,
Alexandra Kadl: Robert M. Berne Cardiovascular Research Center,
Scott F. Walk: Beirne B. Carter Center for Immunology Research,
Daeho Park: Beirne B. Carter Center for Immunology Research,
Robin I. Woodson: Department of Urology,
Marina Ostankovich: Robert M. Berne Cardiovascular Research Center,
Poonam Sharma: Robert M. Berne Cardiovascular Research Center,
Jeffrey J. Lysiak: Department of Urology,
T. Kendall Harden: University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Norbert Leitinger: Department of Pharmacology,
Kodi S. Ravichandran: Beirne B. Carter Center for Immunology Research,

Nature, 2009, vol. 461, issue 7261, 282-286

Abstract: Apoptosis: how cells become targets Apoptosis occurs in essentially all tissues as part of normal development and homeostasis. Yet even in tissues with high cellular turnover, apoptotic cells are rarely seen; this has been attributed to the ability of apoptotic cells to advertise their presence via release of 'find-me' signals to recruit phagocytes and initiate prompt clearance. It has been unclear, however, what type of find-me signals are released by apoptotic cells and how these are sensed by phagocytes. In this paper apoptotic cells are shown to release ATP and UTP that act as a 'find me ' signal and chemoattractant for phagocytes expressing the P2Y2 ATP/UTP receptor.

Date: 2009
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DOI: 10.1038/nature08296

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