ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

Diego Alvarado, Daryl E. Klein and Mark A. Lemmon ()
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Diego Alvarado: University of Pennsylvania School of Medicine, 809C Stellar-Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104-6059, USA
Daryl E. Klein: University of Pennsylvania School of Medicine, 809C Stellar-Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104-6059, USA
Mark A. Lemmon: University of Pennsylvania School of Medicine, 809C Stellar-Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104-6059, USA

Nature, 2009, vol. 461, issue 7261, 287-291

Abstract: ErbB2 regulation and cancer The tyrosine kinase receptor ErbB2/HER2 has been implicated in cancer, in particular in breast cancer. It has been suggested that ErbB2 is constitutively activated as it lacks the extracellular tether that keeps other EGF receptor family members inactive unless they are occupied by ligand. However, Alvarado et al. now present evidence for an alternative mechanism of autoinhibition that keeps the only family member in Drosophila, dEGFR, inactive. dEGFR is most closely related to ErbB2, and the autoinhibitory interactions found in dEGFR are conserved in ErbB2, which has implications for approaches to therapeutically target ErbB2.

Date: 2009
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DOI: 10.1038/nature08297

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