Implications of chimaeric non-co-linear transcripts

Thomas R. Gingeras
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Thomas R. Gingeras: Cold Spring Harbor Laboratory

Nature, 2009, vol. 461, issue 7261, 206-211

Abstract: Abstract Deep sequencing of 'transcriptomes' — the collection of all RNA transcripts produced at a given time — from worms to humans reveals that some transcripts are composed of sequence segments that are not co-linear, with pieces of sequence coming from distant regions of DNA, even different chromosomes. Some of these 'chimaeric' transcripts are formed by genetic rearrangements, but others arise during post-transcriptional events. The 'trans-splicing' process in lower eukaryotes is well understood, but events in higher eukaryotes are not. The existence of such chimaeric RNAs has far-reaching implications for the potential information content of genomes and the way it is arranged.

Date: 2009
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DOI: 10.1038/nature08452

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