Kaplan et al. reply

Rosandra N. Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns, Zhenping Zhu, Daniel Hicklin, Yan Wu, Jeffrey L. Port, Nasser Altorki, Elisa R. Port, Davide Ruggero, Sergey V. Shmelkov, Kristian K. Jensen, Shahin Rafii, David Lyden and J. Wels
Additional contact information
Rosandra N. Kaplan: Department of Pediatrics and the Children’s Blood Foundation Laboratories,
Rebecca D. Riba: Department of Pediatrics and the Children’s Blood Foundation Laboratories,
Stergios Zacharoulis: Department of Pediatrics and the Children’s Blood Foundation Laboratories,
Anna H. Bramley: Department of Pediatrics and the Children’s Blood Foundation Laboratories,
Loïc Vincent: Genetic Medicine and
Daniel D. MacDonald: Department of Pediatrics and the Children’s Blood Foundation Laboratories,
David K. Jin: Genetic Medicine and
Koji Shido: Genetic Medicine and
Scott A. Kerns: Department of Pediatrics and the Children’s Blood Foundation Laboratories,
Zhenping Zhu: Imclone Systems Incorporated
Daniel Hicklin: Imclone Systems Incorporated
Yan Wu: Imclone Systems Incorporated
Jeffrey L. Port: ‖ Surgery, Weill Cornell Medical College of Cornell University, 1300 York Avenue and
Nasser Altorki: ‖ Surgery, Weill Cornell Medical College of Cornell University, 1300 York Avenue and
Elisa R. Port: # Surgery, Memorial Sloan-Kettering Cancer Center, 1233 York Avenue, New York, New York 10021, USA. dcl2001@med.cornell.edu
Davide Ruggero: Fox Chase Cancer Center
Sergey V. Shmelkov: Department of Pediatrics and the Children’s Blood Foundation Laboratories,
Kristian K. Jensen: Department of Pediatrics and the Children’s Blood Foundation Laboratories,
Shahin Rafii: Howard Hughes Medical Institute,
David Lyden: Department of Pediatrics and the Children’s Blood Foundation Laboratories,
J. Wels: Department of Pediatrics and the Children’s Blood Foundation Laboratories,

Nature, 2009, vol. 461, issue 7262, E5-E5

Abstract: Abstract Replying to: M. R. Dawson et al. Nature 461, 10.1038/nature08254 (2009) Commenting on ref. 1, Dawson et al. 2 claim that metastasis formation is independent of VEGFR1 activity, contradicting work by us and many others, including the original description of flt1TK-/- (VEGFR1-TK-/-) mice in the metastatic setting3. Contrasting the findings by Dawson et al.2, here we show that VEGFR1 knockdown in myelomonocytic cells eradicates micro- and macrometastases in a non-amputation/resection tumour model.

Date: 2009
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DOI: 10.1038/nature08261

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