KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints

David N. Ciccone, Hui Su, Sarah Hevi, Frédérique Gay, Hong Lei, Jeffrey Bajko, Guoliang Xu, En Li and Taiping Chen ()
Additional contact information
David N. Ciccone: Epigenetics Program,
Hui Su: Epigenetics Program,
Sarah Hevi: Epigenetics Program,
Frédérique Gay: Epigenetics Program,
Hong Lei: Epigenetics Program,
Jeffrey Bajko: Epigenetics Program,
Guoliang Xu: The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
En Li: Epigenetics Program,
Taiping Chen: Epigenetics Program,

Nature, 2009, vol. 461, issue 7262, 415-418

Abstract: Genomic imprinting: histone demethylation precedes DNA methylation Differential DNA methylation of paternal and maternal alleles regulates the parental origin-specific expression of imprinted genes in mammals, but it is unclear how particular imprinted loci are selected for de novo DNA methylation during gametogenesis. Here, AOF1/KDM1B is shown to be a histone H3 lysine 4 (H3K4) demethylase that is expressed in growing oocytes and required for the establishment of DNA methylation at certain imprinted genes. This suggests that demethylation of H3K4 plays an important role in the formation of DNA methylation imprints at these loci during oogenesis.

Date: 2009
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DOI: 10.1038/nature08315

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