Caught in the activation

Yi Liu
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Yi Liu: Intellikine, Inc., 10931 North Torrey Pines Road, La Jolla, California 92037, USA. yi@intellikine.com

Nature, 2009, vol. 461, issue 7263, 484-485

Abstract: A crystal structure reveals how a protein kinase is activated by the binding of a small molecule at a pocket far from the catalytic site. This opens the door to the design of modulators of protein phosphorylation.

Date: 2009
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DOI: 10.1038/461484a

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