Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

Edward Owusu-Ansah and Utpal Banerjee ()
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Edward Owusu-Ansah: Cell and Developmental Biology
Utpal Banerjee: Cell and Developmental Biology

Nature, 2009, vol. 461, issue 7263, 537-541

Abstract: Reactive oxygen's good side While largely studied because of their harmful effects in DNA damage, protein/lipid oxidation and apoptosis, there is a growing appreciation that reactive oxygen species (ROS) may have beneficial effects in some tissues. In the mammalian haematopoietic system, haematopoietic stem cells contain low ROS levels, but unexpectedly, the common myeloid progenitors (CMPs), produce significantly elevated levels of ROS. Edward Owusu-Ansah and Utpal Banerjee have discovered the apparent functional significance of this difference in ROS level in the two progenitor types in Drosophila. They show that the developmentally regulated, moderately high ROS level in the progenitor population sensitizes them to differentiation, and establishes a signalling role for ROS in the regulation of haematopoietic cell fate.

Date: 2009
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DOI: 10.1038/nature08313

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