Active turnover modulates mature microRNA activity in Caenorhabditis elegans

Saibal Chatterjee and Helge Großhans ()
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Saibal Chatterjee: Friedrich Miescher Institute for Biomedical Research, PO Box 2543, CH-4002 Basel, Switzerland
Helge Großhans: Friedrich Miescher Institute for Biomedical Research, PO Box 2543, CH-4002 Basel, Switzerland

Nature, 2009, vol. 461, issue 7263, 546-549

Abstract: Recycling silencing complexes The class of small RNAs known as microRNAs play important roles in shaping gene expression profiles during development, by binding to and inhibiting, or silencing, the translation of certain messenger RNAs. It is thought that miRNAs were one factor responsible for the evolution of unicellular organisms into multicellular organisms. Saibal Chatterjee and Helge Groβhans report that after miRNAs have acted on a target mRNA and are released from the silencing complex, the ribonuclease XRN-2 promotes their degradation. In this way, XRN-2 acts as a homeostatic regulator of miRNA levels, which may be important in responding to new developmental cues.

Date: 2009
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DOI: 10.1038/nature08349

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