Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling

Masaaki Torii (), Kazue Hashimoto-Torii, Pat Levitt and Pasko Rakic ()
Additional contact information
Masaaki Torii: Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
Kazue Hashimoto-Torii: Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
Pat Levitt: Keck School of Medicine of USC, Los Angeles, California 90089, USA
Pasko Rakic: Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA

Nature, 2009, vol. 461, issue 7263, 524-528

Abstract: Neural development: of columns and clones A feature of the development of the cerebral cortex in the embryo is the migration of neocortical excitatory neurons along radial glial fibres. Less studied than this movement along columnar structures is the regulation and outcome of the tangential mixing of clonal populations of neural progenitors migrating from their origin and encountering those travelling from other proliferative units. Rakic and colleagues report evidence that EphA/ephrin-A signalling modulates this mixing of populations during circuit development. In the absence of ephrin-A, tangential migration is disrupted, leading to impaired lateral dispersion and abnormal columnar organization. Aberrant columnar organization is thought to cause functional impairment within circuits.

Date: 2009
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature08362 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:461:y:2009:i:7263:d:10.1038_nature08362

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08362

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().