Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules

Shuizi Rachel Yu, Markus Burkhardt, Matthias Nowak, Jonas Ries, Zdeněk Petrášek, Steffen Scholpp, Petra Schwille () and Michael Brand ()
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Shuizi Rachel Yu: Developmental Genetics, Biotechnology Center, TUD,
Markus Burkhardt: Biophysics, Biotechnology Center, TUD, and,
Matthias Nowak: Developmental Genetics, Biotechnology Center, TUD,
Jonas Ries: Biophysics, Biotechnology Center, TUD, and,
Zdeněk Petrášek: Biophysics, Biotechnology Center, TUD, and,
Steffen Scholpp: Developmental Genetics, Biotechnology Center, TUD,
Petra Schwille: Biophysics, Biotechnology Center, TUD, and,
Michael Brand: Developmental Genetics, Biotechnology Center, TUD,

Nature, 2009, vol. 461, issue 7263, 533-536

Abstract: Morphogens keep it simple Concentration gradients of certain molecules termed 'morphogens' are known to control tissue development during embryogenesis. Yu et al. have addressed the little understood question of how such gradients form. They use an advanced and highly precise technology for imaging molecules in vivo (fluorescence correlation spectroscopy) to show that freely diffusing Fgf8 morphogen gradients in living zebrafish embryos arise from a simple source–sink mechanism.

Date: 2009
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DOI: 10.1038/nature08391

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