Direct reprogramming of human neural stem cells by OCT4

Jeong Beom Kim, Boris Greber, Marcos J. Araúzo-Bravo, Johann Meyer, Kook In Park, Holm Zaehres and Hans R. Schöler ()
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Jeong Beom Kim: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Boris Greber: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Marcos J. Araúzo-Bravo: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Johann Meyer: Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
Kook In Park: BK21 Project for Medical Sciences, Yonsei University College of Medicine, 250 Seongsanno, Seodaemoon-gu, Seoul 120-752, Korea
Holm Zaehres: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Hans R. Schöler: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany

Nature, 2009, vol. 461, issue 7264, 649-653

Abstract: Human iPS cells made simpler Earlier this year Hans Schöler's group reported that a single transcription factor, OCT4, was sufficient to reprogram mouse adult neural stem cells to pluripotency, making them capable of producing virtually any cell type in the right conditions. This was a striking simplification of the process — OCT4 was just one of four factors used in the early (2006/7) and classic work on producing iPS (induced pluripotent stem) cells. Now Schöler and colleagues show that OCT4 alone can also generate iPS cells from human neural stem cells.

Date: 2009
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DOI: 10.1038/nature08436

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