Discovery of Atg5/Atg7-independent alternative macroautophagy

Yuya Nishida, Satoko Arakawa, Kenji Fujitani, Hirofumi Yamaguchi, Takeshi Mizuta, Toku Kanaseki, Masaaki Komatsu, Kinya Otsu, Yoshihide Tsujimoto and Shigeomi Shimizu ()
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Yuya Nishida: Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
Satoko Arakawa: Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
Kenji Fujitani: Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
Hirofumi Yamaguchi: Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
Takeshi Mizuta: Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
Toku Kanaseki: Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
Masaaki Komatsu: Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku, Tokyo 113-8613, Japan
Kinya Otsu: Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Yoshihide Tsujimoto: Department of Medical Genetics,
Shigeomi Shimizu: Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Nature, 2009, vol. 461, issue 7264, 654-658

Abstract: A second type of macroautophagy In a process known as macroautophagy, defective proteins and entire organelles are sequestered in membrane compartments called autophagosomes that ultimately fuse with lysososmes and undergo degradation. This pathway is activated in response to conditions such as starvation, allowing a cell to break up its own reserves to provide nutrients. At the molecular level, macroautophagy is regulated by Atg genes that are components of the ubiquitin-like conjugation system. Nishida et al. describe a second mode of autophagy that is independent of the Atg genes and is induced under certain stress conditions in vitro and in the clearance of organelles during erythroid maturation in vivo. Future studies will reveal the mechanistic basis for this pathway.

Date: 2009
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DOI: 10.1038/nature08455

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