Direct RNA sequencing

Fatih Ozsolak (), Adam R. Platt, Dan R. Jones, Jeffrey G. Reifenberger, Lauryn E. Sass, Peter McInerney, John F. Thompson, Jayson Bowers, Mirna Jarosz and Patrice M. Milos ()
Additional contact information
Fatih Ozsolak: Helicos BioSciences Corporation, One Kendall Square, Cambridge, Massachusetts 02139, USA
Adam R. Platt: Helicos BioSciences Corporation, One Kendall Square, Cambridge, Massachusetts 02139, USA
Dan R. Jones: Helicos BioSciences Corporation, One Kendall Square, Cambridge, Massachusetts 02139, USA
Jeffrey G. Reifenberger: Helicos BioSciences Corporation, One Kendall Square, Cambridge, Massachusetts 02139, USA
Lauryn E. Sass: Helicos BioSciences Corporation, One Kendall Square, Cambridge, Massachusetts 02139, USA
Peter McInerney: Helicos BioSciences Corporation, One Kendall Square, Cambridge, Massachusetts 02139, USA
John F. Thompson: Helicos BioSciences Corporation, One Kendall Square, Cambridge, Massachusetts 02139, USA
Jayson Bowers: Helicos BioSciences Corporation, One Kendall Square, Cambridge, Massachusetts 02139, USA
Mirna Jarosz: Helicos BioSciences Corporation, One Kendall Square, Cambridge, Massachusetts 02139, USA
Patrice M. Milos: Helicos BioSciences Corporation, One Kendall Square, Cambridge, Massachusetts 02139, USA

Nature, 2009, vol. 461, issue 7265, 814-818

Abstract: A direct line to the transcriptome Understanding the functional output of the genome — the sum total of messenger RNAs in a cell or cell population, known as the transcriptome — is an essential step on the way to understanding biology. Current methods for studying the transcriptome rely on microarray and sequencing approaches that require complementary DNA synthesis followed by multiple manipulations, which introduce biases and potential artefacts. Now a team based at Helicos BioSciences Corporation has developed a direct single-molecule RNA sequencing technique that when scaled-up promises a bias-free high-throughput transcriptome analysis.

Date: 2009
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DOI: 10.1038/nature08390

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