Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

David L. Thomas, Chloe L. Thio, Maureen P. Martin, Ying Qi, Dongliang Ge, Colm O’hUigin, Judith Kidd, Kenneth Kidd, Salim I. Khakoo, Graeme Alexander, James J. Goedert, Gregory D. Kirk, Sharyne M. Donfield, Hugo R. Rosen, Leslie H. Tobler, Michael P. Busch, John G. McHutchison, David B. Goldstein and Mary Carrington ()
Additional contact information
David L. Thomas: Johns Hopkins University, Baltimore, Maryland 21205, USA
Chloe L. Thio: Johns Hopkins University, Baltimore, Maryland 21205, USA
Maureen P. Martin: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA, and Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts 02114, USA
Ying Qi: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA, and Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts 02114, USA
Dongliang Ge: Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
Colm O’hUigin: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA, and Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts 02114, USA
Judith Kidd: Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Kenneth Kidd: Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Salim I. Khakoo: Imperial College
Graeme Alexander: University of Cambridge
James J. Goedert: Infections & Immunoepidemiology Branch, National Cancer Institute, Rockville, Maryland 20852, USA
Gregory D. Kirk: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Sharyne M. Donfield: Rho, Inc., Chapel Hill, North Carolina 27517, USA
Hugo R. Rosen: University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Leslie H. Tobler: Blood Systems Research Institute, San Francisco, California 94118, USA
Michael P. Busch: Blood Systems Research Institute, San Francisco, California 94118, USA
John G. McHutchison: School of Medicine, Duke University, Durham, North Carolina 27705, USA
David B. Goldstein: Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
Mary Carrington: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA, and Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts 02114, USA

Nature, 2009, vol. 461, issue 7265, 798-801

Abstract: IL28B and hepatitis C Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, leading in many cases to chronic liver disease. Here the authors show that an SNP recently identified to associate with response to HCV drug treatment also associates with viral clearance. This study identifies the strongest and most significant genetic effect associated with natural clearance of HCV, implicating a primary role for IL28B in this process.

Date: 2009
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DOI: 10.1038/nature08463

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