Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans

Marta Artal-Sanz () and Nektarios Tavernarakis ()
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Marta Artal-Sanz: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion 71110, Crete, Greece
Nektarios Tavernarakis: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion 71110, Crete, Greece

Nature, 2009, vol. 461, issue 7265, 793-797

Abstract: Prohibitin and longevity: make a brake for it Prohibitins are ubiquitous, evolutionarily conserved proteins that form a ring-like structure at the inner membrane of mitochondria. What they do precisely, we don't know. Marta Artal-Sanz and Nektarios Tavernarakis now show that prohibitin increases lifespan of the nematode worm Caenorhabditis elegans by modulating mitochondrial function and fat metabolism. But in diapause mutants, or worms on a restricted diet, the presence of prohibitin actually shortens life. The authors propose that prohibitin promotes longevity by acting as a brake on the worm's energy supply — moderating fat use and energy production. But, under adverse external conditions, such as limited nutrient availability, energy demands outstrip supply and life lasts longer without such brake.

Date: 2009
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DOI: 10.1038/nature08466

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