STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Hiroki Ishikawa, Zhe Ma and Glen N. Barber ()
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Hiroki Ishikawa: University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Zhe Ma: University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Glen N. Barber: University of Miami Miller School of Medicine, Miami, Florida 33136, USA

Nature, 2009, vol. 461, issue 7265, 788-792

Abstract: Where is thy STING? The adaptor protein STING ('stimulator of interferon genes', also known as MITA and ERIS) is emerging as an important component of the innate immune system's response to microbial DNA. Ishikawa et al. show that in the absence of STING the sensitivity of mice to infection by several DNA and RNA viruses is enhanced. STING-mediated interferon induction requires STING to relocalize with TANK-binding kinase 1 from the endoplasmic reticulum to Sec5-containing endosome vesicles. This work implies that STING is essential for host defence against DNA pathogens such as herpes simplex virus.

Date: 2009
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DOI: 10.1038/nature08476

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