A secreted complement-control-related protein ensures acetylcholine receptor clustering

Marie Gendrel, Georgia Rapti, Janet E. Richmond and Jean-Louis Bessereau ()
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Marie Gendrel: ENS
Georgia Rapti: ENS
Janet E. Richmond: University of Illinois, Chicago, Illinois 60607, USA
Jean-Louis Bessereau: ENS

Nature, 2009, vol. 461, issue 7266, 992-996

Abstract: Synapse organization link to CCP changes For nerves to communicate efficiently with their target cells, the sites of neurotransmitter release must be properly aligned with zones of higher receptor densities. Working on the genetically tractable worm Caenorhabditis elegans, Gendrel et al. show that muscle cells secrete the protein LEV-9, which in turn interacts with LEV-10 to control proper clustering of the acetylcholine receptor. Surprisingly, LEV-9's synaptic function relies on 'control complement protein' (CCP) domains, known until now for their possible involvement in the mammalian immune system. The many CCP proteins that are produced in the mammalian brain might similarly control synapse organization, rather than immune functions.

Date: 2009
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DOI: 10.1038/nature08430

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