Spatiotemporal control of cell signalling using a light-switchable protein interaction

Anselm Levskaya, Orion D. Weiner, Wendell A. Lim () and Christopher A. Voigt
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Anselm Levskaya: The Cell Propulsion Lab, UCSF/UCB NIH Nanomedicine Development Center,
Orion D. Weiner: The Cell Propulsion Lab, UCSF/UCB NIH Nanomedicine Development Center,
Wendell A. Lim: The Cell Propulsion Lab, UCSF/UCB NIH Nanomedicine Development Center,
Christopher A. Voigt: The Cell Propulsion Lab, UCSF/UCB NIH Nanomedicine Development Center,

Nature, 2009, vol. 461, issue 7266, 997-1001

Abstract: Cell biology's leading lights Green fluorescent protein and other genetically encodable optical reporters have revolutionized the study of cell function. Now Levskaya et al. describe a technology that adds a new dimension to cell biology by incorporating light-activated proteins from plants into mammalian cell signalling systems, leading to cells whose morphology and behaviour can be controlled by light. The system uses a reversible protein–protein interaction module from the Arabidopsis phytochrome-signalling network to reversibly translocate activators of the Rho-family GTPases to the plasma membrane. In principle, this advance makes it possible to design a variety of light-programmable reagents for a new generation of perturbative cell biology experiments.

Date: 2009
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DOI: 10.1038/nature08446

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