The postsynaptic function of type II cochlear afferents

Catherine Weisz, Elisabeth Glowatzki and Paul Fuchs ()
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Catherine Weisz: The Department of Neuroscience,
Elisabeth Glowatzki: The Department of Neuroscience,
Paul Fuchs: The Department of Neuroscience,

Nature, 2009, vol. 461, issue 7267, 1126-1129

Abstract: A pathway for traumatic sound It is something of a paradox that partial hearing loss can be associated with hyperacusis, heightened sensitivity to loud, or even moderate sound. The underlying mechanism is unknown, as indeed it is for 'acoustic pain' evoked by traumatic sound among normal hearers. Experiments using gigaohm-seal intra-fibre recording and dye-labelling in isolated rat cochleas now establish the long-mysterious type II cochlear afferent neurons as a potential pathway to signal traumatic sound. These receive synaptic inputs from cochlear outer hair cells, and in an analogy to somatic C-fibres, are activated by ATP, known to be released during tissue damage. During traumatically loud sound, hair cell activity combined with released ATP may provide the adequate 'stimulus' for these anatomically unique type II cochlear afferents.

Date: 2009
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DOI: 10.1038/nature08487

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