Sleep deprivation impairs cAMP signalling in the hippocampus

Christopher G. Vecsey, George S. Baillie, Devan Jaganath, Robbert Havekes, Andrew Daniels, Mathieu Wimmer, Ted Huang, Kim M. Brown, Xiang-Yao Li, Giannina Descalzi, Susan S. Kim, Tao Chen, Yu-Ze Shang, Min Zhuo, Miles D. Houslay and Ted Abel ()
Additional contact information
Christopher G. Vecsey: Neuroscience Graduate Group,
George S. Baillie: Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical and Life Sciences, University of Glasgow
Devan Jaganath: University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Robbert Havekes: University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Andrew Daniels: University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Mathieu Wimmer: Neuroscience Graduate Group,
Ted Huang: Neuroscience Graduate Group,
Kim M. Brown: Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical and Life Sciences, University of Glasgow
Xiang-Yao Li: University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada
Giannina Descalzi: University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada
Susan S. Kim: University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada
Tao Chen: University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada
Yu-Ze Shang: University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada
Min Zhuo: University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada
Miles D. Houslay: Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical and Life Sciences, University of Glasgow
Ted Abel: University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

Nature, 2009, vol. 461, issue 7267, 1122-1125

Abstract: Lost sleep, found memories It is well known that sleep deprivation can have cognitive consequences, including learning and memory deficits, but the mechanisms by which sleep deprivation affects brain function remain unknown. New experiments identify the cyclic AMP pathway as a functional target of sleep deprivation, specifically the impairment of cAMP/PKA-based plasticity in the hippocampus. Rescuing cAMP signalling using phosphodiesterase inhibitors also rescues the memory deficits, pointing to cAMP/PKA signalling enhancers as a possible therapeutic approach to counteract the cognitive effects of lost sleep.

Date: 2009
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DOI: 10.1038/nature08488

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