What recent ribosome structures have revealed about the mechanism of translation

T. Martin Schmeing () and V. Ramakrishnan ()
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T. Martin Schmeing: MRC Laboratory of Molecular Biology
V. Ramakrishnan: MRC Laboratory of Molecular Biology

Nature, 2009, vol. 461, issue 7268, 1234-1242

Abstract: Ribosomes in translation In this Review, Venkatraman Ramakrishnan, joint winner of the 2009 Nobel Prize for chemistry, and his colleague Martin Schmeing, consider recent progress in studies of the structure and function of the ribosome. Focusing primarily on the main aspects of bacterial translation, which should be common for the synthesis of all proteins, they show how knowledge of ribosome structure is increasingly driving sophisticated biochemical and genetic experimentation. In addition to its impact on basic translation research, knowledge of bacterial structures provides a framework for the development of better antibiotics. For a video interview with Venkatraman Ramakrishnan, go to the Nature Video YouTube channel on http://www.youtube.com/user/NatureVideoChannel .

Date: 2009
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DOI: 10.1038/nature08403

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