A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila

Kuniaki Saito, Sachi Inagaki, Toutai Mituyama, Yoshinori Kawamura, Yukiteru Ono, Eri Sakota, Hazuki Kotani, Kiyoshi Asai, Haruhiko Siomi () and Mikiko C. Siomi ()
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Kuniaki Saito: Keio University School of Medicine
Sachi Inagaki: Keio University School of Medicine
Toutai Mituyama: Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST)
Yoshinori Kawamura: Keio University School of Medicine
Yukiteru Ono: Information and Mathematical Science Laboratory, Inc.
Eri Sakota: Japan Biological Informatics Consortium (JBIC)
Hazuki Kotani: Keio University School of Medicine
Kiyoshi Asai: Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST)
Haruhiko Siomi: Keio University School of Medicine
Mikiko C. Siomi: Keio University School of Medicine

Nature, 2009, vol. 461, issue 7268, 1296-1299

Abstract: A regulatory circuit for Piwi A class of small RNAs, piRNAs, interact with PIWI domain-containing Argonaute proteins. Germline piRNAs derive from repetitive DNA and are produced by an amplification process. Recently piRNAs have also been found to be encoded by protein-coding genes in somatic cells. In this work, Siomi and colleagues show that the traffic jam (tj) locus, encoding the Maf transcription factor, encodes a piRNA cluster. These piRNAs are produced in the cytoplasm without amplification, and target FasIII for silencing. Maf itself activates Piwi expression. Thus, the tj locus encodes both an enhancer of Piwi and the piRNAs that interact with Piwi.

Date: 2009
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DOI: 10.1038/nature08501

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