Regulation of cortical microcircuits by unitary GABA-mediated volume transmission

Szabolcs Oláh, Miklós Füle, Gergely Komlósi, Csaba Varga, Rita Báldi, Pál Barzó and Gábor Tamás ()
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Szabolcs Oláh: Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged H-6726, Hungary
Miklós Füle: Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged H-6726, Hungary
Gergely Komlósi: Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged H-6726, Hungary
Csaba Varga: Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged H-6726, Hungary
Rita Báldi: Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged H-6726, Hungary
Pál Barzó: University of Szeged, Semmelweis utca 6, Szeged H-6725, Hungary
Gábor Tamás: Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged H-6726, Hungary

Nature, 2009, vol. 461, issue 7268, 1278-1281

Abstract: Neurotransmission without wires Many receptors for neurotransmitters are found outside neuronal synapses and can be activated by excess neurotransmitter spilling out of the synaptic cleft. But neurotransmitter reuptake by extrasynaptic transporters has been thought to limit the significance of such extrasynaptic signals. Now Tamás and colleagues show that a poorly described cell type of the cerebral cortex, the neurogliaform cells, release the inhibitory neurotransmitter GABA as a large and dense cloud and thus do not require synapses to produce inhibitory responses in the vast majority of neighbouring neurons. They further show that neurosteroids suppress these neurogliaform cells' excitability, which may explain the role of these hormones in post-partum depression and premenstrual syndrome.

Date: 2009
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DOI: 10.1038/nature08503

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