Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Kendle M. Maslowski, Angelica T. Vieira, Aylwin Ng, Jan Kranich, Frederic Sierro, Di Yu, Heidi C. Schilter, Michael S. Rolph, Fabienne Mackay, David Artis, Ramnik J. Xavier, Mauro M. Teixeira and Charles R. Mackay ()
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Kendle M. Maslowski: Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Angelica T. Vieira: Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Aylwin Ng: Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Jan Kranich: Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Frederic Sierro: Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Di Yu: Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Heidi C. Schilter: Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Michael S. Rolph: Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Fabienne Mackay: Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
David Artis: School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Ramnik J. Xavier: Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Mauro M. Teixeira: Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil
Charles R. Mackay: Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia

Nature, 2009, vol. 461, issue 7268, 1282-1286

Abstract: GPR43 receptor as anti-inflammatory target Recent evidence has suggested that the products of 'friendly' intestinal microbes can help counter inflammatory disease and Type 1 diabetes in the host. Commensal bacteria in the colon are known to ferment dietary fibres to produce short-chain fatty acids, and now a study of a mouse model of colitis shows that these fatty acids down-regulate innate and inflammatory responses by stimulating the chemoattractant receptor GPR43 on neutrophils. This identifies interactions between short-chain fatty acids and GPR43 as a possible target for the manipulation of immune responses.

Date: 2009
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DOI: 10.1038/nature08530

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