Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells

Siqin Bao, Fuchou Tang, Xihe Li, Katsuhiko Hayashi, Astrid Gillich, Kaiqin Lao and M. Azim Surani ()
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Siqin Bao: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
Fuchou Tang: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
Xihe Li: College of Life Science, Inner Mongolia University/Mengniu RB CO. Ltd., West No. 1 Daxue Road, Huhhot, Inner Mongolia 010021, China
Katsuhiko Hayashi: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
Astrid Gillich: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
Kaiqin Lao: Molecular Cell Biology, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA
M. Azim Surani: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK

Nature, 2009, vol. 461, issue 7268, 1292-1295

Abstract: Epiblasts regain pluripotency The pluripotent state, first established in the primitive ectoderm cells of the blastocyst-stage embryo, is lost during subsequent development. Bao et al. now show that advanced post-implantation epiblast cells from mouse embryos aged up to 7.5 days can be reprogrammed back to pluripotency by exposure to LIF/STAT3 signalling. They show accompanying changes in the transcriptome (the total mRNA in the cell) results in a loss of the phenotypic and epigenetic memory found in epiblast cells. Cells reprogrammed in this way can contribute to somatic tissues and germ cells in chimaeras, unlike self-renewing epiblast stem cells. This work provides a model for studying how signalling and epigenetic reprogramming may promote reacquisition of pluripotency.

Date: 2009
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DOI: 10.1038/nature08534

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